Areas of Expertise:
My research expertise encompasses the following key areas centered on the development of ultrasound-responsive microbubbles for theranostic applications:
Physicochemical and Acoustic Engineering of Ultrasound-Responsive Lipid Microbubbles
Rational engineering of lipid microbubbles with tunable structural, physicochemical, and acoustic properties for enhanced molecular imaging, cavitation-mediated bioeffects, and targeted therapeutic delivery.
Multiscale Bioeffects of Microbubble–Ultrasound Interactions
Investigation of multiscale biological and biophysical responses to microbubble–ultrasound interactions as governed by microbubble physicochemical properties, acoustic parameters, and in vivo pharmacokinetics.
Targeted Microbubbles for Ultrasound Molecular Imaging
Development of ligand-functionalized microbubbles for targeted binding to disease-specific biomarkers using acoustic radiation force, with mechanistic investigation of the molecular and biophysical determinants governing receptor adhesion, to enable highly sensitive, real-time, and noninvasive ultrasound molecular imaging.
Cavitation-Mediated Drug Delivery and Sonoporation
Engineering microbubbles for the encapsulation and targeted delivery of therapeutic agents, enabling spatiotemporally controlled ultrasound-triggered release, cavitation-mediated sonoporation, and enhanced cellular uptake for theranostic applications.
Translational research
My research is driven by a translational vision focused on transforming fundamental discoveries into clinically actionable technologies for precision diagnosis and therapy. By integrating biomaterials engineering, ultrasound-responsive systems, and targeted therapeutics, my work seeks to address unmet clinical needs and deliver transformative solutions with direct impact on patient care and human health.
Impactful Outcomes
The ultimate outcome of my research is the development of transformative biomedical technologies that address critical clinical needs by improving disease diagnosis, targeted therapy, and real-time therapeutic monitoring.
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